Not all remedies can be taken in combination with citrus, so in order to prevent further complications, you should read the manual before consuming new drug against epilepsy, cancer, depression, high cholesterol levels and for reducing pressure.
Citrus can actually cause interactions with more than 40 drugs no matter if it’s taken as jam or raw. According to some experts, the side effects from it can be consequence of the drugs, but there are also chances that the consequences are due to the combination of these drugs and the fruits. It should also be mentioned that the more drugs are taken, the greater are the chances of side effects and interactions.
Almost all drugs which are taken are going directly to the liver with help of so- called microtonal liver enzymes. They have protein structure which is why they can inhibit or stimulate. CYP3A is among the most important enzymes and it participates in the metabolism– biotransformation up to 70% of all medicines and substances.
The consumption of grapefruit juice inhibits the enzymes CYP1A2 and CYP3A4. Bioflavonoid naringenin and furanocoumarin dihidronergamontin are the main ingredients of this fruit and they inhibit inside the microtonal liver enzymes.
The enzyme inhibition is the most common mechanism of drug interactions and it depends of the taken dose. The competition is carried out in the active place of the enzyme.
For instance, there is a greater risk for cardiac arrhythmia if you take antiarrhythmic “amiodarone” along with a liter or more grapefruit juice per day. Moreover, your heart may stop working if you consume large amounts of grapefruit juice several days before using verapamil.
Be careful when taking drugs because only 2 cups or around 400 ml of grapefruit juice can lead to inhibition of the enzymes. In order to prevent health complications, make sure to read the guideline of every medicine before you take it. according to experts, you should not eliminate grapefruit from your diet, but you just need to be very careful when it comes to its consumption in combination with certain drugs.